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Status:

COMPLETED

Broccoli Sprout Extract in Preventing Lung Cancer in Smokers

Lead Sponsor:

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Collaborating Sponsors:

National Cancer Institute (NCI)

Conditions:

Lung Cancer

Eligibility:

All Genders

18+ years

Phase:

NA

Brief Summary

RATIONALE: Chemoprevention is the use of certain drugs or substances to keep cancer from forming, growing, or coming back. The use of broccoli sprout extract may prevent lung cancer. PURPOSE: This cl...

Detailed Description

OBJECTIVES: Primary * Evaluate the effect of broccoli sprout extract on levels of DNA adducts in participants who smoke. * Determine the effectiveness of broccoli sprout extract in reducing tobacco-...

Eligibility Criteria

Inclusion

  • DISEASE CHARACTERISTICS:
  • Current smoker with ≥ 30 pack-year history of smoking
  • PATIENT CHARACTERISTICS:
  • Performance status
  • ECOG 0-2
  • Life expectancy
  • Not specified
  • Hematopoietic
  • WBC \> 4,000/mm\^3
  • Platelet count \> 100,000/mm\^3
  • Hepatic
  • Bilirubin ≤ 1.5 mg/dL
  • Renal
  • Creatinine ≤ 1.5 mg/dL
  • Other
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile participants must use effective contraception
  • No other medical condition that would preclude study treatment or compliance
  • No gastrointestinal condition that would affect absorption, preclude taking oral medication, or necessitate IV alimentation
  • PRIOR CONCURRENT THERAPY:
  • Surgery
  • No prior surgery affecting absorption
  • Other
  • More than 6 weeks since prior vitamins, herbal supplements, non-steroidal anti-inflammatory drugs, or antibiotics
  • No concurrent dietary intake of cruciferous vegetables

Exclusion

    Key Trial Info

    Start Date :

    January 1 2005

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ESTIMATED

    End Date :

    Estimated Enrollment :

    70 Patients enrolled

    Trial Details

    Trial ID

    NCT00255775

    Start Date

    January 1 2005

    Last Update

    August 9 2010

    Active Locations (1)

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    Page 1 of 1 (1 locations)

    1

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    Baltimore, Maryland, United States, 21231-2410