Status:
COMPLETED
Cognitive Behavioral Therapy for the Treatment of Depression-Related Insomnia
Lead Sponsor:
University of Rochester
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Depression
Eligibility:
All Genders
25-65 years
Phase:
NA
Brief Summary
This study will determine the effectiveness of cognitive behavioral therapy (CBT) in treating insomnia symptoms that are secondary to depression. This study will also determine how long the benefits o...
Detailed Description
Insomnia, characterized by an inability to initiate and maintain sleep, is a defining feature of mood disorders such as depression. CBT has been found to be an effective treatment for depression-relat...
Eligibility Criteria
Inclusion
- History of recurrent depression with the age of onset between 20 and 40 years of age
- At least one depressive episode within 2 years prior to study entry
- At least three discrete depressive episodes within 10 years prior to study entry
- Successful treatment for or resolution of last episode of depression
- Participants whose depression is in remission are eligible for study enrollment. Criteria for remission includes more than 3 consecutive weeks during which the patient does not meet DSM-IV criteria for depression; a Hamilton Rating Depression Scale score less than 6 and a Beck Depression Inventory (BDI) less than 6; no feelings of depression for at least 6 months prior to study entry; and have not taken depression medication for at least 3 months prior to study entry. Once enrolled in the study, these participants must score less than 6 on the weekly BDIs for the first 3 weeks of the study.
- Have experienced mental stability between depressive episodes
- Willing to discontinue over-the-counter or naturopathic remedies for insomnia or depression during the study
- Able to write and speak English fluently
Exclusion
- Current use of maintenance antidepressant therapy
- History of a failure to respond to citalopram treatment
- Unstable medical or psychiatric illness other than major depressive disorder
- History of seizures or head injury
- Current substance or alcohol abuse
- Symptoms suggestive of sleep disorders other than insomnia
- Pregnancy or plan to become pregnant within 2 years of study entry
Key Trial Info
Start Date :
July 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2007
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00255905
Start Date
July 1 2004
End Date
July 1 2007
Last Update
June 28 2013
Active Locations (1)
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1
University of Rochester Sleep and Neurophysiology Research Lab
Rochester, New York, United States, 14642