Status:
COMPLETED
Inflammation and the Host Response to Injury (Burns)
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Trauma
Burns
Eligibility:
All Genders
Brief Summary
The purpose of this study is to help improve our understanding of the biology involved in the body's response to serious trauma or burn injury. The host response to trauma and burns is a collection of...
Detailed Description
This large-scale collaborative project provides the means to acquire the necessary new knowledge directly in humans. Knowledge will be acquired using diverse state-of-the-art genomic and proteomic tec...
Eligibility Criteria
Inclusion
- Burn patients of all ages with 20% or greater of total body surface area burns that require surgical treatment
- Burn patients admitted to the burn unit within 96 hours (4 days) of burn injury
- All patients meeting these criteria are entered into the epidemiologic database and assessed for specific exclusion criteria to establish whether serial blood draws are warranted.
Exclusion
- Injury caused by chemical agent
- Deep injury caused by conduction of electrical current or charge
- Decision not to treat due to severity of injury
- Anoxic brain injury that is not expected to result in complete recovery
- Associated multiple injuries exclusive of burns (ISS \>=25)
- Pre-morbid condition: Severe congestive heart failure (measured ejection fraction \<20%)
- Pre-morbid condition: Malignancy currently under treatment
- Pre-morbid condition: Medical condition requiring systemic glucocorticoid treatment
- Pre-morbid condition: current systemic immunosuppression for organ transplant or chronic inflammatory condition
Key Trial Info
Start Date :
April 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2018
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT00257244
Start Date
April 1 2004
End Date
September 1 2018
Last Update
March 7 2019
Active Locations (4)
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1
Loyola University Medical Center at Loyola in Chicago
Maywood, Illinois, United States, 60153
2
Southwestern Medical Center at University of Texas Southwestern
Dallas, Texas, United States, 75390
3
University of Texas at Galveston-Shriners Burn Hospital- Galveston
Galveston, Texas, United States, 77550
4
Harborview Medical Center at University of Washington
Seattle, Washington, United States, 98104