Status:
COMPLETED
Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2
Lead Sponsor:
Danish Headache Center
Collaborating Sponsors:
EUROHEAD
Conditions:
Familial Hemiplegic Migraine Type 1 and 2
Healthy Volunteers
Eligibility:
All Genders
Phase:
NA
Brief Summary
The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to GTN infusion.
Detailed Description
Glyceryl trinitrate (GTN) induces migraine attacks indistinguishable from spontaneous attacks in approximately 80% of migraine sufferers. After systemic administration GTN is transformed to nitric oxi...
Eligibility Criteria
Inclusion
- Patients: Diagnosis of familial hemiplegic migraine (IHS-classification criteria) caused by mutations in the CACNA1A gene and the ATP1A2 gene.
- Controls: healthy volunteers
Exclusion
- Controls: No primary headache in their own history
- Patients and controls:
- A history of cerebrovascular disease and other CNS- disease
- A history of serious somatic and mental disease
- A history suggesting ischaemic heart disease
- A history of hypo- or hypertension
- Daily intake of medication apart from oral contraceptives
- Abuse of alcohol or medicine (opioid analgesics).
- Pregnant or breastfeeding women.
- On the study day:
- No intake of a simple analgesic in the previous 48 hours
- No headache in the previous 48 hours
Key Trial Info
Start Date :
April 1 2005
Trial Type :
INTERVENTIONAL
End Date :
March 1 2006
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00257985
Start Date
April 1 2005
End Date
March 1 2006
Last Update
August 1 2006
Active Locations (1)
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1
Danish Headache Center, University of Copenhagen, Department of Neurology, Glostrup Hospital
Glostrup, Copenhagen, Denmark, DK-2600