Status:
COMPLETED
PROMISS: Simvastatin Prevents the Contrast Induced Acute Renal Failure in Patients With Renal Insufficiency Undergoing Coronary Angiography
Lead Sponsor:
Seoul National University Hospital
Conditions:
Kidney Failure
Eligibility:
All Genders
19+ years
Phase:
PHASE4
Brief Summary
The contrast induced kidney toxicity has been known to affect the mortality and morbidity in the patients undergoing coronary angiography. But the mechanism and therapeutic strategy for it is not well...
Detailed Description
The simvastatin may prevent the contrast agent induced acute renal failure in the patients with underlying renal insufficiency who is undergoing the coronary angiography. The effect may derive from th...
Eligibility Criteria
Inclusion
- Angina patients
- Patients who is required the coronary catheterization
- creatinine clearance rates ≤60 mL/min using the Cockcroft-Gault formula Patients who undergo coronary catheterization
- Age of 19 or over 19
Exclusion
- pregnancy
- lactation
- having received contrast media within 7 days of study entry
- emergent coronary angiography
- acute renal failure
- end-stage renal disease requiring dialysis
- history of hypersensitivity reaction to contrast media
- cardiogenic shock
- pulmonary edema
- multiple myeloma
- mechanical ventilation
- parenteral use of diuretics
- use of N-acetylcysteine
- use of metformin or nonsteroidal anti-inflammatory drugs within 48 hours of the procedure.
Key Trial Info
Start Date :
February 1 2005
Trial Type :
INTERVENTIONAL
End Date :
March 1 2006
Estimated Enrollment :
320 Patients enrolled
Trial Details
Trial ID
NCT00259441
Start Date
February 1 2005
End Date
March 1 2006
Last Update
July 12 2007
Active Locations (1)
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1
Seoul National University Hospital , Cardiovascular Center
Seoul, South Korea