Status:
COMPLETED
Cognitive Remediation for Schizophrenia
Lead Sponsor:
US Department of Veterans Affairs
Conditions:
Schizophrenia
Eligibility:
All Genders
18-64 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the efficacy of an innovative, computer driven cognitive rehabilitation program for unemployed veterans with schizophrenia.
Detailed Description
Schizophrenia leads to a striking array of negative outcomes, including profound deficits in the ability to fulfill desired and expected community roles. Chronic under employment and unemployment are ...
Eligibility Criteria
Inclusion
- Current DSM-IV diagnoses of schizophrenia or schizoaffective disorder
- Stable clinical course and antipsychotic treatment on a new generation antipsychotic other than clozapine and/or a dose of first generation antipsychotic equivalent to 10 mg. or less of haloperidol for one month prior to enrollment
- Age between 18 and 64 years
- Voluntary consent after receiving full information about the study
Exclusion
- Documented history of neurological disorder or significant head trauma with extended loss of consciousness
- Physical limitations (e.g., with hearing or vision) that would interfere substantially with the use of computer-based exercises
- Current treatment with a first generation antipsychotic medication at a dose equivalent to more than 10 mg. of haloperidol
- Current treatment with benztropine mesylate at a daily does greater than 4 mg
- Current treatment with trihexyphenidyl at a daily dose greater than 15 mg
- Current treatment that combines benztropine mesylate with trihexyphenidyl
- Current treatment with diphenhydramine
- Current competitive employment or participation (current or within past 3 months) in a program designed to secure competitive employment (e.g., CWT)
- Mini Mental Status Examination (MMSE) score of less than 23
- Diagnosis of current Substance Dependence according to DSM-IV criteria
Key Trial Info
Start Date :
November 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2007
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00261794
Start Date
November 1 2004
End Date
September 1 2007
Last Update
January 6 2010
Active Locations (1)
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1
VA Maryland Health Care System, Baltimore
Baltimore, Maryland, United States, 21201