Status:
TERMINATED
The Canadian Glaucoma Study
Lead Sponsor:
Dalhousie University
Collaborating Sponsors:
Canadian National Institute for the Blind
Glaucoma Research Society of Canada
Conditions:
Glaucoma
Eligibility:
All Genders
Phase:
NA
Brief Summary
Glaucoma is a disease which affects between one and two percent of all individuals aged over 40 years. According to recent Canadian National Institute for the Blind figures, it is the second largest s...
Detailed Description
Elevated intraocular pressure is the most important known risk factor for the development and progression of open-angle glaucoma. While pressure reduction is beneficial in many cases, a significant pr...
Eligibility Criteria
Inclusion
- Best corrected visual acuity of at least 6/9.
- Previous visual field examinations showing nerve fibre bundle visual field defects characteristic of open-angle glaucoma and/or previous optic nerve head photographs showing cupping or notching characteristic of open-angle glaucoma.
- Total visual field damage \[in the eligibility visual field (see Section 6.1)\] of between 2 and 10 dB using the visual field index Mean Deviation.46
- Access to patient's previous ocular history and availability of initial untreated intraocular pressure (minimum of three readings).
- (d) Normal non-closable angles by gonioscopy. (e) Willingness to participate in the study and to give informed consent.
Exclusion
- Non-glaucomatous ocular disease.
- Systemic disease known to affect the visual field or ability to participate in the study.
- Systemic beta-blockers.
- Chronic ocular medication other than for glaucoma.
- Previous incisional ocular surgery.
- (e) Distance refraction exceeding 6.00 diopters equivalent sphere or 2.50 diopters of astigmatism.
- (f) Aphakia or pseudophakia. (g) Contact lens wear.
Key Trial Info
Start Date :
February 1 1995
Trial Type :
INTERVENTIONAL
End Date :
June 1 1995
Estimated Enrollment :
430 Patients enrolled
Trial Details
Trial ID
NCT00262626
Start Date
February 1 1995
End Date
June 1 1995
Last Update
December 7 2005
Active Locations (4)
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1
University of British Columbia
Vancouver, British Columbia, Canada, V5Z 3N9
2
Dalhousie University
Halifax, Nova Scotia, Canada, B3H 2Y9
3
University of Toronto
Toronto, Ontario, Canada, M5T 2S8
4
University of Montreal
Montreal, Quebec, Canada, H1T 2H1