Status:
COMPLETED
Cardiovascular Risk Factor Management in HIV Infection
Lead Sponsor:
University Hospital, Basel, Switzerland
Collaborating Sponsors:
Swiss National Science Foundation
Bristol-Myers Squibb
Conditions:
Coronary Heart Disease
Dyslipidemia
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
There is growing evidence that antiretroviral therapy (ART) increases the risk of coronary heart disease (CHD) through metabolic side effects, such as dyslipidemia, insulin resistance, and type II dia...
Detailed Description
Evidence from the D.A.D. study, an international cohort study which includes a large proportion of SHCS patients, suggests that exposure to antiretroviral therapy (ART) increases the risk of coronary ...
Eligibility Criteria
Inclusion
- For analysis of the primary endpoint:
- All individuals in the SHCS
- aged 18 or older
- have a cohort visit in the 12 months preceding the randomisation date with a complete baseline dataset on CHD risk factors
- For analysis of secondary endpoints:
- All individuals in the SHCS
- aged 18 or older
- have a cohort visit in the 12 months preceding the randomisation date with a complete baseline dataset on CHD risk factors
- at least 3 months of ART and at moderate to high risk of CHD (10% 10 years risk of CHD according to the Framingham risk score).
Exclusion
- Pregnant females
- Patients in the SHCS not receiving ART
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
4097 Patients enrolled
Trial Details
Trial ID
NCT00264394
Start Date
July 1 2006
End Date
February 1 2010
Last Update
May 28 2015
Active Locations (7)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospital Basel
Basel, Canton of Basel-City, Switzerland, CH-4031
2
Division des Maladies Infectieuses, Hopital Universitaire Geneve
Geneva, Canton of Geneva, Switzerland, CH-1211
3
Division Maladies Infectieuses, Hopital Universitaire Vaudois (CHUV)
Lausanne, Canton of Vaud, Switzerland, CH-1011
4
Departement Innere Medizin Kantonsspital St. Gallen
Sankt Gallen, Canton Saint Gall, Switzerland, CH-9007