Status:
ACTIVE_NOT_RECRUITING
Real-Time Image Guided Lymphatic Mapping and Nodal Targeting in Lung Cancer
Lead Sponsor:
Dana-Farber Cancer Institute
Collaborating Sponsors:
Brigham and Women's Hospital
Beth Israel Deaconess Medical Center
Conditions:
Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The primary purpose of this study is to determine if we can identify the first lymph node that drains from the tumor, and thus would be the most likely site for metastatic disease, and remove it for a...
Detailed Description
* This study is designed to determine the feasibility, safety amd dosing for indocyanine green and near-infrared fluorescent light in order to maximize the near infrared-guided detection of tumor-spec...
Eligibility Criteria
Inclusion
- Suspected or histologically documented new non-small cell carcinoma that have agreed to undergo a thoracotomy for segmentectomy, lobectomy, bilobectomy or pneumonectomy as recommended by their thoracic surgeon for treatment
- Surgically resectable lung cancer
- N2 lymph nodes negative on PET scan or mediastinoscopy
- Age \> or equal to 18 years of age
- Men, women of non-child bearing age or women with a negative pregnancy test
Exclusion
- Patient does not want to undergo subsequent surgical resection
- Medical condition such as uncontrolled infection or cardiac disease that, i the opinion of the treating surgeon, makes resection unreasonably hazardous for the patient.
- T4 or N2 disease
- Pre-operative spirometry that suggests they cannot undergo resection of their primary tumor by segmentectomy, lobectomy, bilobectomy, or pneumonectomy
- Iodide or seafood allergy
- Pregnant or lactating women
Key Trial Info
Start Date :
February 18 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2029
Estimated Enrollment :
57 Patients enrolled
Trial Details
Trial ID
NCT00264602
Start Date
February 18 2009
End Date
December 1 2029
Last Update
November 7 2025
Active Locations (4)
Enter a location and click search to find clinical trials sorted by distance.
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
2
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02115
3
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
4
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115