Status:

COMPLETED

The Impact of Renin-angiotensin System on Brain Activation During Hypoglycaemia in Healthy Men, a PET Study

Lead Sponsor:

Hypoglycaemia Research Group

Collaborating Sponsors:

Rigshospitalet, Denmark

Conditions:

Hypoglycemia

Cognitive Impairment

Eligibility:

MALE

18-40 years

Phase:

NA

Brief Summary

The purpose of this study is to evaluate the cerebral blood flow in subjects with high and low activity in the renin-angiotensin system (RAS).The renin-angiotensin system is a hormone system which is ...

Detailed Description

The purpose of this study is to evaluate the regional cerebral blood flow in subjects with high and low activity in the renin-angiotensin system (RAS). Earlier studies have shown that high RAS activit...

Eligibility Criteria

Inclusion

  • Male Age 18-40 years Right-handed In good general health based on history High/low RAS activity (high ACE activity, A-allele for angiotensin II receptor (subtype 2) and high plasma angiotensinogen, or low ACE activity, low plasma angiotensinogen and not carrier of the A-allele for angiotensin II receptor (subtype 2)).
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Exclusion

  • Any evidence of mental, neurological or medical illnesses. The presence of ferromagnetic metal in the body. Claustrophobia Exposure to radiation within the last year
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Key Trial Info

Start Date :

January 1 2006

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

February 1 2008

Estimated Enrollment :

20 Patients enrolled

Trial Details

Trial ID

NCT00264641

Start Date

January 1 2006

End Date

February 1 2008

Last Update

March 29 2017

Active Locations (1)

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Medical Department I, Hillerød Hospital

Hillerød, Hillerød, Denmark, 3400