Status:
TERMINATED
Treatment of Refractory Status Epilepticus
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Status Epilepticus
Eligibility:
All Genders
16+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine whether propofol or barbiturates should be preferred in the treatment of status epilepticus (continuous seizure activity) refractory to 2 standard antiepilept...
Detailed Description
Refractory status epilepticus (SE) develops in 31%-44% of patients with SE, with a mortality of 16%-23%. Coma induction is advocated for its management. Propofol and barbiturates are the most used age...
Eligibility Criteria
Inclusion
- Patients with refractory status epilepticus not due to cerebral anoxia, needing coma induction for clinical management.
Exclusion
- Age \< 16 years old.
- Known pregnancy.
- Cerebral anoxia as SE etiology.
- Epilepsia partialis continua (simple partial SE).
- Known intolerance to the study drugs.
- Known mitochondrial disorder, hyperlipidemia, or significant rhabdomyolysis.
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT00265616
Start Date
May 1 2006
End Date
March 1 2010
Last Update
April 9 2013
Active Locations (5)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
2
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
3
Inselspital
Bern, Canton of Bern, Switzerland
4
CHUV
Lausanne, Canton of Vaud, Switzerland