Status:
TERMINATED
Leptin in Human Energy and Neuroendocrine Homeostasis
Lead Sponsor:
Columbia University
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Obesity
Weight Loss
Eligibility:
All Genders
19-45 years
Phase:
NA
Brief Summary
Previous work in our laboratory, and many others, has shown that body weight is regulated. When anyone, fat or thin, tries to maintain a reduced body weight, many systems affecting energy balance (ske...
Detailed Description
The failure of obesity treatments to sustain weight reduction is widely recognized. The central hypotheses of these studies are that: 1) Energy and neuroendocrine homeostatic systems are altered durin...
Eligibility Criteria
Inclusion
- Healthy lean or overweight males and females who have sustained their current weight for at least 6 months.
Exclusion
- Pregnancy
- Any illness or chronic medication that affect energy expenditure, neuroendocrine function, autonomic function or that would impair ability to tolerate a prolonged hospital stay including rapid weight reduction and vigorous exercise.
Key Trial Info
Start Date :
July 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00265980
Start Date
July 1 2002
End Date
July 1 2013
Last Update
September 18 2019
Active Locations (1)
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1
Columbia University
New York, New York, United States, 10032