Status:
TERMINATED
Studies of Disorders in Antibody Production and Related Primary Immunodeficiency States
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Hyper-IgM Syndrome
Ectodermal Dysplasia
Eligibility:
All Genders
Brief Summary
This study investigates gene abnormalities in Primary Immune Deficiency(PID) with a goal of improving the diagnosis and treatment of patients. The specific disorders include: 1. X linked hyper IgM S...
Detailed Description
This protocol is designed to study the genetics and pathophysiology of Hyper-IgM syndrome, NEMO associated immune deficiency, patients with related primary immune deficiency disorders, and the blood r...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- All patients must have a known or suspected immune defect with hyper-IgM syndrome and/or disorders of immunoglobulin production. There will be no limit on age, sex, race, or disability. Normal volunteers must be healthy adults between the age of 18 and 70 years. All study participants enrolled on to this study must agree to allow PI to store research samples. Refusal to let PI store samples may lead to withdrawal fro this specific study.
- EXCLUSION CRITERIA:
- The presence of an acquired abnormality, which leads to immune defects, such as HIV, chemotherapy, and malignancy are general exclusion criteria. Refusal to let us store samples may lead to withdrawal from this specific study. Other factors, which are in the judgment of the Principal Investigator PI that may interfere with patient evaluation or determine to pose an added risk for study participants are also criteria for exclusion.
Exclusion
Key Trial Info
Start Date :
December 14 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 11 2013
Estimated Enrollment :
119 Patients enrolled
Trial Details
Trial ID
NCT00266513
Start Date
December 14 2005
End Date
July 11 2013
Last Update
October 6 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892