Status:
COMPLETED
Brain Changes in Adolescents While Imagining and Observing Aggressive Behavior
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Aggressive Behavior
Eligibility:
MALE
14-17 years
Brief Summary
This study will use functional magnetic resonance imaging (fMRI) to examine what happens in the brains of adolescents when they are exposed to violent media and how imagining aggressive behavior affec...
Detailed Description
Objective. The purpose of the protocol is to localize the prefrontal cortical regions mediating aggressive behavior. Utilizing two different experimental neuropsychological tasks during functional MRI...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- In all the studies, participants will consist of male adolescent healthy, native English-speaking, right-handed volunteers. Participants will range in age from 14 to 17 years old and they will be included regardless of race.
- EXCLUSION CRITERIA:
- Non-native English speakers and non-right handers will be excluded, as will non-neurologically normal volunteers. Subjects younger than 14 and older than 17 years of age will be excluded.
- Subjects with any of the following will be excluded from MRI testing: aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant; ocular foreign body, such as metal shavings; permanent eyeliner; insulin pump; or irremovable body piercing will be excluded from the study due to the possible dangerous effects of the magnet upon metal objects in the body.
- Individuals with a neurological or psychiatric history, including significant aggressive behavior and drug abuse, or with a medical condition that would compromise our interpretation of the fMRI results will be excluded. Adolescents with attentional, cognitive, or learning difficulties or impairments cannot take part in the study. An intelligence quotient less then 80 will be exclusion criteria for this study. Individuals with a current or past history of post-traumatic stress disorder or other psychiatric disorders or individuals with a history of physical or sexual abuse will be excluded as they may be disturbed by the exposure to violent stimuli. Furthermore, we will exclude adolescents who take centrally acting medications. The presence or absence of these conditions will be determined by a standardized neuropsychiatric interview, questionnaires, ability testing, and standard phone or in-person intake (see screening section).
- Adolescents who have been trained in martial arts will be excluded from our studies.
Exclusion
Key Trial Info
Start Date :
December 14 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 12 2010
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT00267891
Start Date
December 14 2005
End Date
August 12 2010
Last Update
July 2 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892