Status:
COMPLETED
Early Lactate-Directed Therapy in the Intensive Care Unit (ICU)
Lead Sponsor:
Erasmus Medical Center
Collaborating Sponsors:
Medical Center Rijnmond Zuid, Rotterdam
Sint Franciscus Gasthuis
Conditions:
Tissue Hypoxia
Hyperlactatemia
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Blood lactate levels have long been related to tissue hypoxia, a severe condition in critically ill patients associated with the development of organ system failure and subsequent death. Increased blo...
Detailed Description
Tissue hypoxia can be defined as a state in which tissue oxygen demand is not met by tissue oxygen delivery (DO2). The presence and persistence of tissue hypoxia is related to the development of organ...
Eligibility Criteria
Inclusion
- Patients admitted to the general ICU with an admission lactate level of ≥ 3,0 mmol/l
- Written informed consent
Exclusion
- Liver failure
- Post liver surgery
- Age \< 18 years
- Do not resuscitate status
- Contraindication to central venous or arterial catheterization
- Epileptic seizures (shortly before or during admission)
- Evident aerobic cause of hyperlactatemia
- Judgement of treating physician that study participation is undesirable for medical, medical-ethical or other reasons
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2008
Estimated Enrollment :
350 Patients enrolled
Trial Details
Trial ID
NCT00270673
Start Date
February 1 2006
End Date
March 1 2008
Last Update
April 25 2008
Active Locations (5)
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1
Reinier de Graaf Hospital
Delft, Netherlands
2
Erasmus MC University Medical Center
Rotterdam, Netherlands
3
Ikazia Hospital
Rotterdam, Netherlands
4
Medical Center Rijnmond Zuid
Rotterdam, Netherlands