Status:
COMPLETED
Blood Cell Collection for Future Use in Individuals With Fanconi Anemia
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsors:
Children's Hospital Medical Center, Cincinnati
Conditions:
Fanconi Anemia
Eligibility:
All Genders
1-35 years
Phase:
NA
Brief Summary
Fanconi anemia (FA) is a disease that affects an individual's bone marrow. It is caused by a defective gene in the CD34+ cells, which are responsible for producing various types of blood cells. Indivi...
Detailed Description
FA is a rare, inherited disease that is caused by a gene defect to the CD34+ cells. It primarily affects an individual's bone marrow, resulting in decreased production of blood cells. The lack of whit...
Eligibility Criteria
Inclusion
- Diagnosis of FA
- Normal bone marrow cytogenetics within 3 months of study entry
- Absolute neutrophil count (ANC) level greater than 750
- Hemoglobin level greater than 8 without transfusion
- Platelet level greater than 30,000 without transfusion
- Must weigh at least 7.5 kg
Exclusion
- Myloid or lymphoid leukemia
- Cytogenic abnormalities
- HIV infected
- Neoplastic or non-neoplastic disease of any major organ system that would compromise the ability to withstand the collection procedure
- Uncontrolled infection
- Unable to tolerate general anesthesia
- Known adverse reaction to E. Coli
- Pregnant or breastfeeding
Key Trial Info
Start Date :
August 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2007
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00271089
Start Date
August 1 2004
End Date
October 1 2007
Last Update
July 12 2016
Active Locations (1)
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1
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229