Status:
COMPLETED
A Clinical Trial of Infliximab for Uveitis
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
Centocor, Inc.
Conditions:
Uveitis
Eligibility:
All Genders
9+ years
Phase:
NA
Brief Summary
This project is designed to test the hypothesis that inhibition of binding between tumor necrosis factor alpha (TNF-alpha) and its receptors using Remicade (infliximab, chimeric mouse/human IgG1K mono...
Eligibility Criteria
Inclusion
- The study group will include patients suffering from treatment-resistant vision-threatening uveitis who attend the Uveitis Clinic at Casey Eye Institute.
- We plan to enroll 32 patients.
Exclusion
- Patients with ocular or systemic infection.
- Patients with the subtype of uveitis termed pars planitis who have MRI scan evidence of demyelination. There is a theoretical risk of adverse outcome of TNF-alpha inhibition on the clinical course of multiple sclerosis. Patients who suffer from pars planitis are at increased risk of developing multiple sclerosis.
- Children under the age of 9.
- Patients with known sensitivity to mouse proteins. Remicade is a chimeric protein with human and murine components.
- Patients with history of cancer (exception- skin cancers which are curatively resected), organ transplantation (exception- cornea), recent drug or alcohol addiction, or inability to keep appointments.
- Patients with other serious systemic diseases that could interfere with participation in the study.
- It is specifically noted that pregnant women and nursing mothers will be excluded from this study.
Key Trial Info
Start Date :
August 1 2001
Trial Type :
INTERVENTIONAL
End Date :
December 1 2006
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00273390
Start Date
August 1 2001
End Date
December 1 2006
Last Update
July 4 2011
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