Status:
COMPLETED
Glomerular Injury of Preeclampsia
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsors:
National Center for Research Resources (NCRR)
Conditions:
Pre-Eclampsia
Eligibility:
FEMALE
18+ years
Phase:
NA
Brief Summary
Pre-eclampsia complicates 7 - 10% of pregnancies and constitutes a leading cause of fetal growth retardation and premature birth, as well as infant and maternal morbidity and mortality. The kidney is ...
Detailed Description
OBJECTIVE: To assess the benefit of L-arginine, the precursor to nitric oxide (NO), to blood pressure and recovery of the glomerular lesion in pre-eclampsia. METHODS: 45 women with pre-eclampsia were...
Eligibility Criteria
Inclusion
- \- Women selected for the study were diagnosed with pre-eclampsia in the second half of pregnancy.
- i.) an elevation of blood pressure to levels in excess of 140 systolic over 90 diastolic ii.) proteinuria determined by a urine dipstick value ≥ 2+, or quantitated at ≥ 0.5 g either per gram of creatinine or in a 24 hour urine collection.
Exclusion
- Women with a history of underlying renal disease defined as a pre-pregnancy azotemia (serum creatinine ≥ 1.2 mg/dl) or proteinuria
Key Trial Info
Start Date :
January 1 2000
Trial Type :
INTERVENTIONAL
End Date :
December 1 2003
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00275158
Start Date
January 1 2000
End Date
December 1 2003
Last Update
January 14 2010
Active Locations (1)
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1
Stanford University Medical Center
Stanford, California, United States, 94305