Status:
COMPLETED
Effects of Atorvastatin Versus Probucol on Small Dense LDL
Lead Sponsor:
Yokohama City University Medical Center
Conditions:
Chronic Nephropathy
Eligibility:
All Genders
20-75 years
Phase:
PHASE4
Brief Summary
Small dense low-density lipoprotein (LDL) plays an important role in causing glomerular injury through conversion to an oxidatively modified form of LDL. However, few studies evaluated the effects of ...
Detailed Description
The study is a randomized crossover trial comparing the effect of atorvastatin (10 mg/day) and probucol (500 mg/day) for 24 weeks in 30 patients (urinary albumin excretion 0.3-2.0 g/day, and creatinin...
Eligibility Criteria
Inclusion
- Hyperlipidemic patients with non-diabetic nephropathy
Exclusion
- Endocrinological, hematological or hepatic disease
- Cerebral infarction or hemorrhage
- Homozygous familial hypercholesterolemia
- Uncontrolled hypertension
- Myocardial infarction occurring within the previous 6 months
- Unstable angina
- Diabetic nephropathy
- Abnormal thyroid function
- Receiving steroids or immunosuppressive agents
Key Trial Info
Start Date :
January 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2007
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00276133
Start Date
January 1 2004
End Date
May 1 2007
Last Update
May 9 2007
Active Locations (1)
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1
Yokohama City University Center Hospital
Yokohama, Kanagawa, Japan, 232-0024