Status:
COMPLETED
Sertraline for the Prevention of Recurrent Postpartum Depression
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Depression
Eligibility:
FEMALE
18-45 years
Phase:
PHASE3
Brief Summary
This study will determine the effectiveness of taking sertraline within 24 hours of giving birth in preventing a recurrence of postpartum depression.
Detailed Description
Depression after pregnancy is called postpartum depression and may be caused by a rapid change in hormone levels during and immediately after pregnancy. Researchers believe that it is one of the most ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Pregnant
- Presents by week 36 gestation for first two study visit interviews (interviews may be combined)
- History of DSM-IV Major Depression after the age of 15
- Score no higher than 19 on the 29-item SIGH-ADS at Week 36
- Medically healthy, as determined by a physician
- Exclusion criteria
- Current major depression
- Urine screen positive for drugs
- Currently using other therapies for depression
- DSM-IV diagnoses of bipolar 1 or 2 disorder or any psychotic episode
- History of substance abuse within 6 months prior to study entry
- Has not received any obstetrical care
- Use of medications for medical disorders (except for treatment of stable disorders)
Exclusion
Key Trial Info
Start Date :
December 1 2003
Trial Type :
INTERVENTIONAL
End Date :
August 1 2006
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00276900
Start Date
December 1 2003
End Date
August 1 2006
Last Update
October 7 2013
Active Locations (1)
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1
Women's Behavioral HealthCare Program
Pittsburgh, Pennsylvania, United States, 15213