Status:
COMPLETED
Histamine Pharmacogenetics in Children With Atopic Dermatitis
Lead Sponsor:
Virginia Commonwealth University
Collaborating Sponsors:
American College of Clinical Pharmacy
PPRU
Conditions:
Dermatitis, Atopic
Eligibility:
All Genders
6-5 years
Brief Summary
The primary goal of the study is to investigate the impact of a common genetic polymorphism in a histamine detoxification enzyme that may well have a common role in regulating the expression of atopic...
Detailed Description
Atopic dermatitis (AD) is a common condition in the pediatric population, affecting an estimated 15% of all children greater than 18 months of age in the United States. It is now recognized that AD is...
Eligibility Criteria
Inclusion
- Caucasian, Hispanic and African American children ages 6 months to 5 years with a diagnosis of atopic dermatitis within the last 12 months will constitute the candidate pool for enrollment into the study group. The diagnosis of atopic dermatitis will be determined by the presence of at least 3 major diagnostic features (i.e., pruritis, rash,relapsing-remitting presentation, family history or atopy) in addition to at least 3 minor features (including but not limited to xerosis, elevated serum IgE, ocular involvement, food allergy). Healthy Caucasian, Hispanic and African American children within the same age range will comprise the pool for enrollment into the control group.
Exclusion
- Any child with atopic dermatitis who has a documented history of asthma or bronchospasm or who is currently receiving treatment for either of these conditions will be excluded. Any control subject who has asthma or positive family history of allergy or atopic disease in a first-degree relative (biological mother, father or siblings) will also be ineligible for enrollment.
Key Trial Info
Start Date :
June 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
751 Patients enrolled
Trial Details
Trial ID
NCT00277433
Start Date
June 1 2004
End Date
December 1 2009
Last Update
March 20 2017
Active Locations (7)
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1
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202
2
University of California at San Diego
San Diego, California, United States, 92103
3
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
4
Kosair Charities Pediatric Clinical Research Unit
Louisville, Kentucky, United States, 40202