Status:
COMPLETED
Effects of Intravenous Clonidine on Ocular Blood Flow and Intraocular Pressure
Lead Sponsor:
Medical University of Vienna
Conditions:
Physiology
Eligibility:
MALE
19-35 years
Phase:
PHASE4
Brief Summary
Background Clonidine, a derivate of Imidazol, is an antihypertensive drug. It acts by stimulating adrenergic receptors on nerves in the brain and Imidazol-receptors. As a result, clonidine slows the h...
Eligibility Criteria
Inclusion
- Men aged between 19 and 35 years, nonsmokers
- Body mass index between 15th and 85th percentile
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
- Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant
- Normal ophthalmic findings, ametropy \< 3 Dpt.
Exclusion
- Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
- Treatment in the previous 3 weeks with any drug
- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- History of hypersensitivity to the trial drug or to drugs with a similar chemical structure
- History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with, distribution, metabolism or excretion of study drugs
- Blood donation during the previous 3 weeks
- History or family history of epilepsy
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
End Date :
January 1 2005
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00279253
Start Date
March 1 2004
End Date
January 1 2005
Last Update
January 19 2006
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