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Status:

COMPLETED

Cranberry for Prevention of Urinary Tract Infections in Multiple Sclerosis Patients

Lead Sponsor:

Rennes University Hospital

Collaborating Sponsors:

Pierre Fabre Laboratories

Ministry of Health, France

Conditions:

Multiple Sclerosis

Urinary Tract Infections

Eligibility:

All Genders

18-70 years

Phase:

PHASE3

Brief Summary

Bladder dysfunction occurs at some time in most patients with multiple sclerosis and these patients are prone to have recurrent urinary tract infections. Cranberry has been traditionally used for the ...

Detailed Description

Bladder dysfunction occurs at some time in 70 to 90% of patients with multiple sclerosis and these patients are prone to have recurrent urinary tract infections (UTI), leading to an important morbidit...

Eligibility Criteria

Inclusion

  • Inclusion Criteria:
  • Adults aged 18 to 70, with multiple sclerosis, neurologically stable for at least 3 months
  • With an EDSS score ≥ 3
  • Symptomatic bladder dysfunction: frequency, urgency, dysuria, incontinence (at least one of these symptoms), needing intermittent catheterization or not
  • Ambulatory at inclusion
  • Able to undergo evaluation
  • Informed written consent
  • Non-inclusion Criteria:
  • Regular consumption of cranberry within 3 months before inclusion
  • Symptomatic urinary tract infection at inclusion
  • Chronic renal failure (creatinin clearance \< 10ml/min)
  • Patients with urinary permanent catheterization
  • Patients with hyperuricemia and risk of uric acid lithiasis
  • Patients with oral anticoagulant treatment (antivitamins K)
  • Peptic ulcer
  • Intolerance to cranberry and/or excipients
  • Urinary tract infections antibioprophylaxis

Exclusion

    Key Trial Info

    Start Date :

    January 1 2006

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ACTUAL

    End Date :

    October 1 2008

    Estimated Enrollment :

    171 Patients enrolled

    Trial Details

    Trial ID

    NCT00280592

    Start Date

    January 1 2006

    End Date

    October 1 2008

    Last Update

    May 21 2012

    Active Locations (10)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 3 (10 locations)

    1

    Unité de Médecine Physique et Réadaptation - CHU Jean Minjoz

    Besançon, France, 25030

    2

    Service de Médecine Physique et Réadaptation - Hôpital Pellegrin

    Bordeaux, France, 33076

    3

    Service de Médecine Physique et Réadaptation - Hôpital Raymond Poincaré

    Garches, France, 92380

    4

    Consultations maladies infectieuses et tropicales, Hôpital Raymond Poincaré

    Garches, France