Status:
COMPLETED
Memantine for Corticosteroid-Induced Mood and Declarative Memory Changes
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Physiological Effects of Drugs
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
The purpose of this research is to determine if patients on corticosteroids who are given memantine will show improvement in memory compared to those receiving placebo (an inactive substance). This re...
Detailed Description
Twenty (20) outpatients with pulmonary (e.g. asthma), rheumatic (e.g. rheumatoid arthritis, dermatomyositis) illnesses or renal transplants (all populations we have used in prior clinical trials) rece...
Eligibility Criteria
Inclusion
- Patients between (and including) ages 18-70 and taking at least 5 mg/day of prednisone equivalents for at least 3 months and anticipating continued treatment at the same dose for at least 20 additional weeks will be eligible for enrollment.
Exclusion
- Patients with a history of allergic reaction or other contraindication to memantine therapy or with other unstable medical conditions (e.g. recent myocardial infarction, diabetes with poor glycemic control) will not be allowed to participate.
- Pregnant or nursing women or women of childbearing age who will not use University of Texas Southwestern (UTSW) Institutional Review Board (IRB) approved methods of avoiding pregnancy will be excluded from the study.
- Those with a history of mental retardation, dementia, or other severe cognitive disorders will also be excluded from the study.
- Patients with baseline RAVLT total words recalled normative score \> 55 will be excluded to avoid including persons with exceptionally good declarative memory at baseline.
- Subjects who do not speak English will be excluded because many of the outcome measures used in this study are not validated in languages other than English.
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
End Date :
February 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00280774
Start Date
March 1 2006
End Date
February 1 2007
Last Update
January 25 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Parkland Health and Hospital System (Asthma, Allergy, & Arthritis Clinics)
Dallas, Texas, United States, 75235