Status:

TERMINATED

Fludarabine, Cyclophosphamide, and Rituximab in Treating Patients With Prolymphocytic Leukemia

Lead Sponsor:

German CLL Study Group

Conditions:

Prolymphocytic Leukemia

Eligibility:

All Genders

18-75 years

Phase:

PHASE2

Brief Summary

RATIONALE: Drugs used in chemotherapy, such as fludarabine and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividin...

Detailed Description

OBJECTIVES: * Determine the overall and progression-free survival of patients with B-cell prolymphocytic leukemia treated with immunochemotherapy comprising fludarabine, cyclophosphamide, and rituxim...

Eligibility Criteria

Inclusion

  • DISEASE CHARACTERISTICS:
  • Diagnosis of B-cell prolymphocytic leukemia
  • Previously treated disease
  • All Binet stages allowed
  • PATIENT CHARACTERISTICS:
  • Life expectancy \> 3 months
  • ECOG/WHO performance status 0-3
  • PRIOR CONCURRENT THERAPY:
  • No more than 3 prior treatment regimens

Exclusion

    Key Trial Info

    Start Date :

    September 1 1999

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ESTIMATED

    End Date :

    October 1 2006

    Estimated Enrollment :

    21 Patients enrolled

    Trial Details

    Trial ID

    NCT00281931

    Start Date

    September 1 1999

    End Date

    October 1 2006

    Last Update

    September 26 2016

    Active Locations (1)

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    1

    Helios Klinikum Erfurt

    Erfurt, Germany, 99012