Status:
COMPLETED
Genetics of Rolandic Epilepsy
Lead Sponsor:
King's College London
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Epilepsy
Eligibility:
All Genders
3+ years
Brief Summary
The purpose of this study is to find the genes that cause Rolandic epilepsy and its related traits.
Detailed Description
Rolandic epilepsy (RE) is the most common type of childhood epilepsy-affecting more than 50,000 children in the United States-and has a complex genetic inheritance. The seizure prognosis is relatively...
Eligibility Criteria
Inclusion
- Inclusion:
- typical history of focal seizures
- EEG centrotemporal sharp waves
- age of onset 3-12 years
- no previous epilepsy type (febrile seizures OK)
- normal development
- normal neurological examination
- normal MRI/CT (if done)
- Exclusion:
- only history of secondary generalized seizures
- atypical history/semiology
- history and EEG inconsistent
- abnormal EEG background
- very early (\<3yrs) or late (\>12yrs) onset
- global neurodevelopmental deficit
- deviant neurodevelopment
- structural imaging abnormality
Exclusion
Key Trial Info
Start Date :
January 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT00282854
Start Date
January 1 2005
End Date
December 1 2013
Last Update
June 28 2023
Active Locations (1)
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1
Mailman School of Public Health, Columbia University Medical Center, 722 West 168th St, 6th Floor
New York, New York, United States, 10032