Status:
TERMINATED
Insulin Glargine Injection Treatment in Place of Thiazolidinedione (TZD), Sulfonylurea, or Metformin in Triple Agent Therapy for Type 2 Diabetes Mellitus (T2DM) Adult Subjects With Unsatisfactory Control
Lead Sponsor:
Sanofi
Conditions:
Diabetes Mellitus, Type 2
Eligibility:
All Genders
18-79 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare the change in hemoglobin A1c (HbA1c) from baseline to Week 12 between the 3 treatment arms.
Eligibility Criteria
Inclusion
- Subjects meeting all of the following criteria will be considered for enrollment into the study:
- 18 to 79 years of age, inclusive
- Diagnosis of type 2 diabetes mellitus
- Continuous treatment with therapeutic dosages of a thiazolidinedione (rosiglitazone or pioglitazone), metformin, and a sulfonylurea daily prior to entering the study
- Screening HbA1c ≥ 7.0%
- Fasting C-peptide concentration ≥ 0.27 ng/ml
- Negative glutamic acid decarboxylase (GAD) antibodies
- Demonstrated ability and willingness to perform self-monitoring blood glucose (SMBG) using a plasma-referenced glucose meter and to maintain an electronic diary
- Demonstrated ability and willingness to use an electronic diary to record SMBG results, insulin doses, and hypoglycemic events.
- Signed, informed consent and Health Insurance Portability and Accountability Act (HIPAA) documentation
Exclusion
- Stroke, myocardial infarction, coronary artery bypass graft, percutaneous transluminal coronary angioplasty, or angina pectoris, within the last 12 months
- Cardiac status New York Heart Association (NYHA) III-IV
- Impaired renal function as shown by, but not limited to, serum creatinine ≥ 1.5 mg/dL for males, or ≥ 1.4 mg/dL for females
- Chronic use of insulin: (more than 3 weeks of continuous use) in the past 12 months
- Acute infection
- Clinically significant peripheral edema
- Acute or chronic history of metabolic acidosis, including diabetic ketoacidosis
- Clinical evidence of active liver disease, or serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) 2.5 times the upper limit of the normal range
- History of hypoglycemia unawareness
- Pregnancy or lactation
- Known hypersensitivity to insulin glargine or any of the components of Lantus®
- Known hypersensitivity to insulin glulisine or any of the components of Apidra®
- Any malignancy within the last 5 years, with the exception of adequately treated basal or squamous cell carcinoma of the skin or adequately treated cervical carcinoma in situ
- Current addiction or current alcohol abuse, or history of substance or alcohol abuse within the last 2 years
- Diagnosis of dementia
- Subject is the investigator or any sub-investigator, research assistant, pharmacist, study coordinator, other staff or relative thereof directly involved in the conduct of the protocol
- Mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study. Subject unlikely to comply with protocol, e.g., uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study
- subject is currently taking or was treated with the following medications 3 months prior to screening: Byetta(exenatide), Starlix(nateglinide),Prandin (repaglinide), Januvia(sitagliptin), Janumet(metformin + sitagliptin)
- Any disease or condition that in the opinion of the investigator and/or sponsor may interfere with the completion of the study
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2008
Estimated Enrollment :
390 Patients enrolled
Trial Details
Trial ID
NCT00283049
Start Date
February 1 2006
End Date
November 1 2008
Last Update
January 13 2011
Active Locations (1)
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1
sanofi-aventis, US
Bridgewater, New Jersey, United States, 08807