Status:
COMPLETED
Pharmacogenetics of Anastrozole in Postmenopausal Women With Estrogen Receptor-Positive and/or Progesterone Receptor-Positive Stage I, Stage II, or Stage III Breast Cancer
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Breast Cancer
Eligibility:
FEMALE
18+ years
Brief Summary
RATIONALE: Studying samples of blood in the laboratory from patients with cancer receiving anastrozole may help doctors learn more about changes that occur in DNA and identify biomarkers related to ca...
Detailed Description
OBJECTIVES: * To evaluate the association of intragenic haplotypes in genes encoding proteins involved in anastrozole metabolism pathways with anastrozole steady state plasma levels in postmenopausal...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Diagnosis of breast cancer
- Stage I, II, or III disease
- Resected disease
- Planning to undergo treatment with anastrozole at the clinically approved dose of 1 mg/day OR Mayo Clinic Cancer Center Rochester patient who will be enrolled on or has been enrolled on CAN-NCIC-MA27 and has not started taking the study medication (anastrozole or exemestane)
- Hormone receptor status:
- Estrogen receptor-positive and/or progesterone receptor-positive primary tumor
- PATIENT CHARACTERISTICS:
- Female
- Postmenopausal
- Able to complete questionnaires alone or with assistance
- PRIOR CONCURRENT THERAPY:
- More than 6 months since prior endocrine therapy, except tamoxifen
- No other prior aromatase inhibitors (e.g., letrozole or exemestane)
- No prior ovarian function suppression with surgery or radiotherapy, ovarian ablation, or luteinizing hormone-releasing hormone analogues (e.g., goserelin) as treatment for cancer
Exclusion
Key Trial Info
Start Date :
July 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2010
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT00283608
Start Date
July 1 2005
End Date
March 1 2010
Last Update
May 16 2011
Active Locations (4)
Enter a location and click search to find clinical trials sorted by distance.
1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259-5499
2
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224
3
Mayo Clinic
Rochester, Minnesota, United States, 55905
4
M. D. Anderson Cancer Center at University of Texas
Houston, Texas, United States, 77030-4009