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Status:

UNKNOWN

Salvage: Postconditioning With Adenosine for STEMI

Lead Sponsor:

University Hospital, Gasthuisberg

Conditions:

Acute ST Elevation Myocardial Infarction

Eligibility:

All Genders

Phase:

PHASE2

Brief Summary

Investigate the effect of selective intracoronary administration of adenosine on myocardial salvage and microvascular integrity in the setting of acute myocardial infarction.

Detailed Description

Prospective, single center, randomized clinical study. Study design is random patient assignment to selective intracoronary administration of adenosine or control immediately before restoration of cor...

Eligibility Criteria

Inclusion

  • Myocardial infarction of less than 12 hours duration with symptoms lasting at least 20 minutes.
  • ECG-criteria: ST-segment elevation of \> 0.1 mV in 2 or more limb leads or \> 0.2 mV in 2 or more contiguous precordial leads or presumed new left bundle branch block.
  • Written informed consent prior to inclusion in the study. If this is not possible, verbal informed consent from the patient or written assent of a legally acceptable representative should be obtained, to be followed by written informed consent by the patient at the earliest subsequent opportunity.
  • Adequate vascular access seems possible (femoral pulsation palpable).

Exclusion

  • Contra-indication to heparin, LMWH, clopidogrel.
  • Anticipated difficulty with vascular access.
  • Cardiogenic shock.
  • Inability to give informed consent (or assent).
  • High grade atrioventricular block; severe asthma; treatment with theophylline, glibenclamide (Diamicron) or dipyridamole.
  • Prior CABG.
  • Participation in an investigational drug or device study within the past 30 days.

Key Trial Info

Start Date :

January 1 2006

Trial Type :

INTERVENTIONAL

End Date :

Estimated Enrollment :

100 Patients enrolled

Trial Details

Trial ID

NCT00284323

Start Date

January 1 2006

Last Update

January 31 2006

Active Locations (1)

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Universitaire Ziekenhuizen Leuven

Leuven, Belgium, 3000