Status:
COMPLETED
Integrating the Genetic and Metabolic Faces of Obesity
Lead Sponsor:
Stanford University
Conditions:
Insulin Resistance
Obesity
Eligibility:
All Genders
30-65 years
Phase:
PHASE1
Brief Summary
The goal of this study is to determine why some obese individuals develop insulin resistance and others do not. We hypothesize that an impairment in differentiation of fat cells (adipocytes) is respon...
Detailed Description
Healthy overweight/obese individuals will be screened for insulin resistance. Both insulin resistant individuals and insulin sensitive individuals (to serve as controls) will be eligible to enroll. Fa...
Eligibility Criteria
Inclusion
- nondiabetic defined as fasting plasma glucose \< 126 mg/dL
- body mass index 27 to 35 kg/m2
- no major organ diseases
- able to come to Stanford for regular clinical research center visits
- English speaking or has own translator
Exclusion
- pregnancy/lactation
- history of eating disorder or major psychiatric illness
- allergy to thiazolidinedione
- elevation of liver enzymes (\> 2.5 times upper normal limit)
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT00285844
Start Date
October 1 2005
End Date
October 1 2012
Last Update
December 4 2024
Active Locations (1)
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1
Stanford University
Stanford, California, United States, 94305