Status:
COMPLETED
TEAM-Project: Trial on the Effect of Anesthetics on Morbidity and Mortality
Lead Sponsor:
University Hospital, Basel, Switzerland
Collaborating Sponsors:
Abbott
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Volatile anesthetics may provide some protection from myocardial ischemia, an effect called anesthetic preconditioning. In patients undergoing coronary artery bypass surgery, this preconditioning effe...
Detailed Description
Basic research and animal studies have detected that volatile anesthetics provide some protection from myocardial ischemia, an effect called anesthetic preconditioning. Recent clinical studies have fo...
Eligibility Criteria
Inclusion
- Patients scheduled for a non-cardiac surgical procedure of high or intermediate cardiac risk are eligible if they have documented coronary artery disease (CAD) or are at high risk of CAD.
Exclusion
- Ongoing medication with sulfonylurea derivatives (unless stopped ≥ 2 days before surgery) or theophylline
- Emergency surgery
- Unstable angina pectoris
- Preoperative hemodynamic instability
- Severe hepatic disease
- Renal insufficiency (creatinine clearance \< 30 ml/min)
- Severe chronic obstructive pulmonary disease (forced expiratory volume in 1 second \[FEV1\] \< 1 litre)
- Absence of written patient consent
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2011
Estimated Enrollment :
385 Patients enrolled
Trial Details
Trial ID
NCT00286585
Start Date
February 1 2006
End Date
November 1 2011
Last Update
August 27 2012
Active Locations (3)
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1
Kantonsspital
Liestal, Basel-Landschaft, Switzerland, CH-4410
2
University Hospital
Basel, Basel, Switzerland, CH-4000
3
Bürgerspital
Solothurn, Canton of Solothurn, Switzerland, CH-4500