Status:
UNKNOWN
Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?
Lead Sponsor:
Emerald City Headache Organization
Collaborating Sponsors:
Ortho-McNeil Neurologics, Inc.
Conditions:
Migraine
Chronic Headache
Eligibility:
All Genders
18-55 years
Brief Summary
The purpose of the study is to determine by the use of non-invasive magnetic stimulation if the medication Topiramate adjusts the excitability of the migraine sufferer's brain. Previous studies have ...
Detailed Description
We propose a clinic-based study to test the hypothesis that topiramate modulates the excitability of the occipital cortex in migraine. Subjects between 18 and 55 years old, who have migraine with aura...
Eligibility Criteria
Inclusion
- Subjects 18 to 55 years old with migraine headaches as defined by the International Headache Society (IHS).
- Subjects must be willing to take topiramate for migraine prophylaxis
Exclusion
- 1\. Subjects with frequent tension headaches 2. Subjects with ill-defined head pain 3. Unable to be weaned off other headache prophylaxis. 4. Requiring daily use of centrally-acting medications. 5. Pregnant, lactating and women not on adequate birth control measures. 6. Subjects with a personal or family history of seizures of any type. 7. History of head injury or brain surgery. 8. Cardiac pacemakers or any other implanted electronic device. 9. Subjects with history of headaches or with history of tension-type headaches recurring \>1/month and relieved by over the counter medications.
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Key Trial Info
Start Date :
February 1 2006
Trial Type :
OBSERVATIONAL
End Date :
August 1 2006
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00286923
Start Date
February 1 2006
End Date
August 1 2006
Last Update
February 14 2006
Active Locations (1)
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1
Swedish Headache Clinic
Seattle, Washington, United States, 98104