Status:
COMPLETED
Daily Vitamin K in Patients on Warfarin With Unstable INRs
Lead Sponsor:
University of North Carolina, Chapel Hill
Conditions:
Anticoagulants
Warfarin
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine if daily Vitamin K supplementation stabilizes INRs in patients taking warfarin with a history of frequent dose changes or variable INRs.
Detailed Description
Consistent daily Vitamin K intake may contribute to the stabilization of INR values in patients with unstable INRs on warfarin therapy. Subjects with unstable INRs will be identified from the existing...
Eligibility Criteria
Inclusion
- Patient of UNC Anticoagulation Clinic with INR target of 2.0-3.0 and at least 9 months on uninterrupted warfarin
- Unstable INRs for the past 6 months, defined as a minimum number of warfarin dose changes of 3
- Patient demonstration of proper POC device technique on 2 measurements during one teaching session with investigator
- Age greater than or equal to 18 years
Exclusion
- Stroke or TIA within the previous 12 months
- VTE within the last 3 months
- Antiphospholipid antibody syndrome
- Pregnant patients, since warfarin is contraindicated during pregnancy
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2006
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00287313
Start Date
October 1 2005
End Date
May 1 2006
Last Update
January 12 2010
Active Locations (1)
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1
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599