Status:
COMPLETED
Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery Disease
Lead Sponsor:
Imperial College London
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
30-75 years
Phase:
PHASE2
PHASE3
Brief Summary
The aim of this study is to investigate the effect of genistein administration on coronary arteries in humans. We will measure the size of a coronary artery and the speed and amount of blood flow in r...
Eligibility Criteria
Inclusion
- Aged 30-75 years
- Patients requiring diagnostic coronary angiography
- Presence of coronary artery disease on angiogram but with at least one non-obstructed (lesions \<70% narrowed compared with the adjacent normal part of the vessel) atheromatous vessel (confirmed at diagnostic cardiac catheterisation)
- Female patients must be postmenopausal (FSH\>40 IU/L)
- Willing to give informed, written consent
Exclusion
- Age \<30 or \>75 years
- Allergy to radiographic contrast media
- Sino-atrial disease or significant bradycardia
- Concomitant medication with persantin (dipyridamole) or theophyllines
- Asthma
- Hypertension
- Left ventricular hypertrophy or dysfunction (clinical/ECG/echo/CXR)
- Female patients with FSH\<40 IU/L (postmenopausal)
- Female patients currently taking hormone therapy, or who have taken hormone therapy in previous 6 months
- Unwilling to give written informed consent
- Participation in another study within previous 60 days
Key Trial Info
Start Date :
October 1 1999
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 18 2003
Estimated Enrollment :
71 Patients enrolled
Trial Details
Trial ID
NCT00287690
Start Date
October 1 1999
End Date
August 18 2003
Last Update
August 5 2019
Active Locations (1)
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1
Royal Brompton & Harefield NHS Trust
London, United Kingdom, SW3 6NP