Status:
TERMINATED
Melatonin Effects on Luteinizing Hormone
Lead Sponsor:
Scripps Health
Collaborating Sponsors:
University of California, San Diego
Conditions:
Hot Flashes
Eligibility:
FEMALE
50-70 years
Phase:
PHASE1
PHASE2
Brief Summary
In many mammals, the duration of the nocturnal melatonin elevation regulates seasonal changes in reproductive hormones such as luteinizing hormone (LH). Melatonin's effects on human reproductive endoc...
Detailed Description
Twenty postmenopausal women troubled by hot flashes underwent one week of baseline observation followed by 4 weeks of a randomized controlled trial of melatonin or matched placebo. The three randomize...
Eligibility Criteria
Inclusion
- Postmenopausal woman
- Troubled by hot flashes
Exclusion
- Use of reproductive hormones other than continuous estrogen or progesterone hormone replacement
- Any acute illness
- Any anticipated changes of medication
- Anemia (hemoglobin \<12) or poor veins Recent trans-time-zone jet travel, shift work, or irregular sleep habits Any neurological or pituitary disease
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
End Date :
February 1 2005
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00288262
Start Date
June 1 2004
End Date
February 1 2005
Last Update
February 7 2006
Active Locations (1)
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1
Scripps Clinic Sleep Center
La Jolla, California, United States, 92037