Status:
COMPLETED
Quantifying Abnormalities in Cortical Activation Associated With Auditory Hallucinations Using Functional Magnetic Resonance Imaging
Lead Sponsor:
Vanderbilt University
Collaborating Sponsors:
National Alliance for Research on Schizophrenia and Depression
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The goal of the project is to characterize abnormalities in brain structure and function related to schizophrenia. The investigators will use advanced magnetic resonance imaging (MRI) techniques to me...
Detailed Description
The goal of the project is to characterize abnormalities in brain structure and function related to schizophrenia. We will use advanced magnetic resonance imaging (MRI) techniques to measure the degre...
Eligibility Criteria
Inclusion
- Investigators will study subjects who:
- Are between the ages of 18 and 65.
- Meet diagnostic criteria for any psychiatric disorder with auditory hallucinations (at least one every 20 minutes) including schizophrenia/schizoaffective disorder OR schizophrenia/schizoaffective disorder without auditory hallucinations.
- Have been treated with an antipsychotic drug for hallucinations at least three months or are unmedicated
- Are willing to change their current antipsychotic medication if indicated
- Are able to provide written consent
- Normal controls must :
- Be between the ages of 18 and 65
- Not meet the diagnostic criteria for schizophrenia or schizoaffective disorder or other psychiatric disorder involving hallucinations
- Not currently be treated with an antipsychotic drug
- Be able to provide written consent
Exclusion
- Subjects and normal controls will be excluded from participation if there is:
- Evidence of non-psychiatric, chronic central nervous system (CNS) disease (such as brain injury or neurological disease)
- Contraindication to MRI, including prior claustrophobic reaction and severe movement disorder
- A recent change in menstrual status other than recent changes in oral or implanted contraceptive use (for females)
- A positive pregnancy result (for females)
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2006
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00288340
Start Date
January 1 2006
End Date
August 1 2006
Last Update
April 19 2017
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212