Status:
UNKNOWN
Metoprolol and Formoterol in Chronic Obstructive Pulmonary Disease (COPD)
Lead Sponsor:
Martini Hospital Groningen
Conditions:
Chronic Obstructive Pulmonary Disease (COPD)
Eligibility:
All Genders
40-70 years
Phase:
PHASE4
Brief Summary
We want to study the effect of the combination of metoprolol (a beta-blocker) with formoterol (a beta-agonist) on long function in patients with Chronic Obstructive Pulmonary Disease (COPD). There are...
Eligibility Criteria
Inclusion
- male/female aged between 40-70 inclusive
- COPD defined by GOLD criteria
- FEV1 greater or equal to 60% of predicted without medication
- baseline FEV1 greater or equal than 1.2L
- 10 or more pack years
- no hard contraindications for use of beta blockers
- being able to perform technically acceptable pulmonary function tests
- signed informed consent
- systolic blood pressure equal to 130 or greater
Exclusion
- instable COPD during the month before visit 1
- usage of corticosteroids during the month before visit 1
- significant pulmonary diseases other than COPD
- a history of cancer within the last 5 years (basal cell carcinoma or cutaneous squamous cell carcinoma allowed)
- a recent history of myocardial infarction
- use of an investigational drug within one month or six half lives (which ever is greater) of visit 1
- contra-indications for the use of ipratropium-bromide
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00288548
Start Date
February 1 2006
Last Update
February 20 2006
Active Locations (1)
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1
Martini Hospital
Groningen, Provincie Groningen, Netherlands, 9700 RM