Status:
TERMINATED
Cell Therapy for Coronary Heart Disease
Lead Sponsor:
Johann Wolfgang Goethe University Hospital
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
Impaired contractile function after a heart attack and due to coronary heart disease is a major cause of "heart failure" limiting quality of life and prognosis, which cannot be prevented even with opt...
Detailed Description
* The study is an open-label, controlled, randomized single-center trial. * Patients post myocardial infarction (\>= 3 months) with a patent infarct-related artery are included. * Bone marrow-derived ...
Eligibility Criteria
Inclusion
- Patients aged 18 to 80
- Patients post-myocardial infarction (\> 3 months old) or with diffuse ischemic CHD
- Signed informed consent
Exclusion
- \- Existing neoplastic disease or signs of tumor recurrence within the last 5 years
- Active infection
- Active internal bleeding
- Stroke within the past 2 years
- Surgery or trauma within the past two months
- Uncontrolled hypertension over 160/100
- Arteriovenous malformations or aneurysms
- HIV infection
- Signs of significant kidney or liver failure (creatinine \> 2.0 mg/dL, GOT \> 2 x upper standard value)
- Thrombopenia (\< 100,000)
- Anemia (hemoglobin \< 8.5 g/dL)
- Mental retardation
- Participation in another clinical study
- Women of childbearing age
- Chronic inflammatory disease
Key Trial Info
Start Date :
January 1 2002
Trial Type :
INTERVENTIONAL
End Date :
January 1 2005
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00289822
Start Date
January 1 2002
End Date
January 1 2005
Last Update
November 30 2006
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
J. W. Goethe University Hospitals
Frankfurt, Germany, 60590