Status:
COMPLETED
Effects of Endometriosis on Bone Mineral Density
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Endometriosis
Eligibility:
FEMALE
40-50 years
Brief Summary
This study will compare bone mass in women with a history of endometriosis, a disease in which the lining of the uterus grows on nearby tissues, to that of women who have not had endometriosis. Endome...
Detailed Description
After peaking in the third decade, bone mineral density (BMD) decreases slowly over time, with a more dramatic short-term decline at the time of menopause. Because of the association with osteoporosis...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Regularly cycling women between the ages of 40 and 50 with surgically documented endometriosis (preferably biopsy proven, but unequivocal operative reports may allow inclusion).
- OR
- Regularly cycling women between the ages of 40 and 50 who are healthy volunteers.
- Women will be matched by ethnicity, by BMI within 5 kg/M(2), and by age (at the time of DEXA) in two groups: 40 - 45 years and 45 - 50 years.
- EXCLUSION CRITERIA:
- Women who are pregnant or lactating or who have abnormalities in the medical history or screening laboratory tests that might contribute to abnormal BMD (e.g. hypercalcemia, renal failure) will not be enrolled
- We will not include women who currently or have previously taken medications known to affect bone mineral density (e.g. thyroid hormone suppression, supraphysiologic glucocorticoids, GnRH, dilantin) or those that suggest menstrual abnormalities (fertility drugs), but we will consider other prescription drug use on a case-by-case basis.
Exclusion
Key Trial Info
Start Date :
February 7 2006
Trial Type :
OBSERVATIONAL
End Date :
February 10 2009
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00291278
Start Date
February 7 2006
End Date
February 10 2009
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892