Status:
COMPLETED
Relative Potency of Inhaled Corticosteroids
Lead Sponsor:
St. Joseph's Healthcare Hamilton
Collaborating Sponsors:
GlaxoSmithKline
Conditions:
Asthma
Chronic Obstructive Pulmonary Disease (COPD)
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
To investigate the validity of a clinical model to determine the relative potency of different preparations of inhaled corticosteroids used for the treatment of asthma or of eosinophilic bronchitis wi...
Eligibility Criteria
Inclusion
- Sputum eosinophilia \>3%
- Adults age 18-70 years
- History of episodic wheeze, chest tightness, dyspnea or cough within the last 12 months.
- FEV1 ≥ 60% predicted
- Steroid naive or on not more than 500 µg a day of beclomethasone or equivalent.
- Able to give written informed consent
Exclusion
- Recent asthma or COPD exacerbation (as judged by the clinician) due to respiratory infection within the last month
- Relevant seasonal allergen exposure within 4 weeks or within the course of the study
- Treatment with prednisone or antibiotics or hospitalisation within the past 6 weeks
- Other respiratory diseases
- Women who are pregnant or unwilling to use appropriate contraception during the study
- Unable to withhold short-acting ß-agonist treatment for 6 hours before visit
Key Trial Info
Start Date :
January 1 2001
Trial Type :
INTERVENTIONAL
End Date :
February 1 2007
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00292838
Start Date
January 1 2001
End Date
February 1 2007
Last Update
July 20 2011
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Firestone Institute for Respiratory Health, St. Joseph's Healthcare
Hamilton, Ontario, Canada, L8N 4A6