Status:
UNKNOWN
Effect of Angiotensin II Receptor Blockers (ARB) on Left Ventricular Reverse Remodelling After Aortic Valve Replacement in Severe Valvular Aortic Stenosis
Lead Sponsor:
Odense University Hospital
Conditions:
Aortic Valve Stenosis
Left Ventricular Hypertrophy
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The consequence of aortic valve stenosis (AVS) is increased pressure load on the left ventricle which causes left ventricular (LV) hypertrophy, and myocardial stretch will cause activation of cardiac ...
Detailed Description
1. Background: Aortic valve stenosis (AVS) is the most common valvular disease in the western world. The prevalence increases with age where "degenerative" changes of the aortic valve with thicken...
Eligibility Criteria
Inclusion
- Symptomatic severe AVS referred for valve replacement (mechanic prosthesis or bioprosthesis) at Odense University Hospital
- Signed informed consent
Exclusion
- Severe renal failure (s-creatinine \>300 mmole/l)
- Moderate or severe hepatic failure
- Moderate or severe LV systolic dysfunction (LVEF\<40%)
- Patients already treated with ACE-I or ARB
- Known intolerance for ARB
- Unwilling to participate in the study
- Poor echocardiographic window
- Pregnant women
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2009
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT00294775
Start Date
February 1 2006
End Date
June 1 2009
Last Update
June 30 2009
Active Locations (1)
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1
Cardiology Department, Odense University hospital
Odense, Fyn, Denmark, 5000