Status:
COMPLETED
X-Chromosome Inactivation Status and Premature Ovarian Failure
Lead Sponsor:
University of Pittsburgh
Conditions:
Premature Ovarian Failure
Eligibility:
FEMALE
20-40 years
Brief Summary
Women who are affected with premature ovarian failure will exhibit skewed X-chromosome inactivation patterns compared to women with normal menstrual function (as defined by being pregnant), indicating...
Detailed Description
Premature ovarian failure (POF) affects approximately 1% of women. For most women a cause is not found, but structural abnormalities of the X-chromosome commonly lead to POF, suggesting genes on the X...
Eligibility Criteria
Inclusion
- Women diagnosed with POF.
- A chromosomal analysis must have been performed to evaluate X-chromosomal abnormalities, and the results are known to be normal.
Exclusion
- Patients who have a known etiology for their POF and/or an inability to obtain karyotype results for these patients or unknown X-chromosome abnormalities.
Key Trial Info
Start Date :
November 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2009
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00295087
Start Date
November 1 2005
End Date
October 1 2009
Last Update
December 8 2014
Active Locations (1)
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1
Magee-Womens Hospital
Pittsburgh, Pennsylvania, United States, 15213