Status:
COMPLETED
Expression of BCRP in Icteric Patients
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Icterus
Eligibility:
All Genders
18+ years
Brief Summary
The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Bile acids are also substrates of the drug efflux transporter breast cancer...
Detailed Description
BCRP is capable of transport bile acids and may indicate that this transporter is involved in bile acid homeostasis. As an efflux pump, it could protect the enterocytes from potential toxic bile acid ...
Eligibility Criteria
Inclusion
- clinical diagnosis of obstructive cholestasis (obstructive jaundice was defined on the basis of chemical parameters (bilirubin, g-glutamyltransferase, and alkaline phosphatase) and on imaging procedures (ultrasound and ERCP) demonstrating a dilated bile duct system)
- control subjects had an indication for a gastrointestinal tract endoscopy within a cancer-screening program
Exclusion
- \-
Key Trial Info
Start Date :
June 1 2003
Trial Type :
OBSERVATIONAL
End Date :
August 1 2004
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00295360
Start Date
June 1 2003
End Date
August 1 2004
Last Update
February 23 2006
Active Locations (1)
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1
University Basel, Department of Research
Basel, Canton of Basel-City, Switzerland, 4031