Status:
UNKNOWN
Exercise And Rosuvastatin Treatment: Is There an Anti-Inflammatory Synergy?
Lead Sponsor:
Purdue University
Conditions:
Nonfamilial Hypercholesterolemia
Physical Inactivity
Eligibility:
All Genders
40-65 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether the effects of rosuvastatin treatment and exercise training can be synergistic, with respect to the innate immune receptor TLR4, markers of systemic i...
Detailed Description
Both statin drugs and exercise training are known to exert anti-inflammatory effects. We found that both high levels of physical activity and an exercise training program reduced markers of inflammati...
Eligibility Criteria
Inclusion
- Nonfamilial hypercholesterolemia
- Total cholesterol \>200 mg/dl, LDL \>130 mg/dL
- Physical inactivity
- Moderate to low alcohol intake
Exclusion
- Liver or kidney disease
- Acute illness or infection
- Use of corticosteroids, ACE inhibitors, platelet aggregating inhibitors, thiazolidinediones, and bis-phosphonates.
- Use of cyclosporine, warfarin, gemfibrozil or other lipid lowering agents
- Regular antacid or aspirin use
- Type I \& II diabetes with insulin treatment
- hypothyroidism, and/or renal insufficiency
- Chronic/debilitating osteoarthritis
- Rheumatoid arthritis
- Central or peripheral nervous system disorders
- Anti-depressant medications
- Major affective disorder
- HIV infection or auto-immune disorders
- Use of tobacco products
- unexplained or intended weight loss of \> 2 kg during the previous six months
- Surgery within the previous three months
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
End Date :
August 1 2007
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT00295373
Start Date
February 1 2006
End Date
August 1 2007
Last Update
April 20 2007
Active Locations (1)
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1
Purdue University
West Lafayette, Indiana, United States, 47906