Status:
COMPLETED
A Study to Assess the Safety and Efficacy of an Investigational Drug (MK-686) in Patients With Osteoarthritis (0686-006)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Osteoarthritis
Eligibility:
All Genders
40-65 years
Phase:
PHASE2
Brief Summary
This study is being conducted to assess the safety and tolerability of MK-0686 and to evaluate its efficacy in the treatment of osteoarthritis of the hip or knee in men and women.
Eligibility Criteria
Inclusion
- Patients with a clinical and radiographic diagnosis of osteoarthritis of the hip or knee,either prior NSAID or Acetaminophen users within the ARA functional class I,II or III and with no clinically significant diseases
- Patients required to demonstrate a flare of the signs and symptoms of OA following withdrawal of NSAID treatment
- Prior acetaminophen users also required to demonstrate greater than a defined minimum level of signs and symptoms of OA
- females must be either post-menopausal or surgically sterilized
Exclusion
- No history of concurrent arthritic disease
- No history of neoplastic disease within a specified duration
- No history of disease that causes malabsorption
- Chronic use of certain medications excluded
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2006
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00296569
Start Date
September 1 2005
End Date
May 1 2006
Last Update
December 24 2014
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