Status:
COMPLETED
Effects of n-3 Polyunsaturated Fatty Acids and Antioxidants on Postprandial Hyperlipidemia and Vascular Function in Men
Lead Sponsor:
Laval University
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Cardiovascular Diseases
Vasodilation
Eligibility:
MALE
18-70 years
Phase:
PHASE2
PHASE3
Brief Summary
Diet has long been used as a way to provide enough nutrients to an individual in order to meet metabolic requirements. However, recent scientific advancements have suggested that beyond meeting nutrit...
Eligibility Criteria
Inclusion
- Waist circumference \> 90 cm
- Fasting triglycerides \> 1.7 mmol/L
- No use (ever) of medications for the treatment for dyslipidemia or hypertension
Exclusion
- Alcohol consumption \> 1 drink per day i.e \~15 g of alcohol/day or the equivalent of 1 beer (12 oz or 341 mL), 1 glass of wine (4 oz or 125 mL) or 1 ounce (30 mL) of liquor.
- Chronic use of supplements (vitamins, minerals or flavonoids)
- Body mass index \> 35 kg/m2
- Chronic diseases: CHD, diabetes, etc.
- Smokers (1 or more cigarette/day)
- Dyslipidemia secondary to renal insufficiency, hypothyroidism or others
- Any prior or current use of medications known to affect lipoprotein-lipid metabolism (e.g. statins, fibrates), endothelial function (hypotensive drugs). Use (ever) of anticoagulant drugs (e.g. warfarin) because of possible detrimental interaction with the consumption of cranberry juice. Current or recent (\<2 weeks) use of anti-inflammatory drugs Note: If for any reason, a subject would have to go an any of these drugs during the protocol, they would be automatically dropped from the study.
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
99 Patients enrolled
Trial Details
Trial ID
NCT00296595
Start Date
February 1 2006
End Date
December 1 2008
Last Update
September 22 2015
Active Locations (1)
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1
Institute of Nutraceuticals and Functional Foods
Québec, Quebec, Canada, G1K 7P4