Status:
COMPLETED
Dichotic Listening as a Predictor of Medication Response in Depression
Lead Sponsor:
New York State Psychiatric Institute
Conditions:
Major Depression
Dysthymia
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
PHASE2
Brief Summary
Depressed patients will have hearing tests and then be treated with up to three treatments (i.e., Fluoxetine, Imipramine) until remitted, to see whether test results predict specific outcomes.
Detailed Description
100 depressed patients will be tested with verbal and nonverbal dichotic tests, and then treated sequentially with Fluoxetine and Imipramine until remitted. Preferential hemisphere for auditory proces...
Eligibility Criteria
Inclusion
- Ages between 18-65
- Meets Diagnostic and Statistical Manual, 4th Edition criteria for current Major Depression, Dysthymia or Depression Not Otherwise Specified
Exclusion
- Known hearing impairment
- Active suicidal ideation (history of suicide attempts will be evaluated on a case by case basis)
- Hamilton Rating Scale for Depression, 17-item version \> 20
- Current (past six months) alcohol and/or drug abuse or dependence
- Medical condition likely to require intervention contraindicated with study medication (e.g., known arrhythmia likely to be exacerbated by Imipramine)
- Bipolar I
- Psychosis
- If currently taking antidepressants or mood stabilizers, cannot be off psychotropic medication for 7 weeks (10 weeks for Prozac) or felt to require other psychiatric medication (other than occasional sleep or Anxiety medication)
- Premenopausal women not using known effective birth control
- Not currently depressed (whether considered due to current treatment or not)
- Nonresponse to adequate trial of both study medications (i.e., \> 4weeks on \> escitalopram 30 mg/d, and imipramine 200 mg/d); patients having an inadequate response to one study medication could be enrolled and receive the other; patients having responded to an adequate trial of either study medication would be offered a retrial; also excluded will be subjects having non responded to an adequate trial with citalopram (i.e., \> 4 weeks on \> citalopram 60 mg/d)
- Left-handed
Key Trial Info
Start Date :
April 1 1994
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00296725
Start Date
April 1 1994
End Date
June 1 2011
Last Update
May 30 2019
Active Locations (1)
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1
Depression Evaluation Service, New York State Psychiatric Institute
New York, New York, United States, 10032