Status:
COMPLETED
Radiotherapy - Cerebrovascular Reactivity (RT-CVR Study)
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Princess Margaret Hospital, Canada
Conditions:
Brain Neoplasms
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Brain tumours often have low oxygen levels, and that makes them more resistant to radiation therapy. If patients breathe the right mixture of oxygen during treatment, radiation may work better. In thi...
Eligibility Criteria
Inclusion
- Patients with primary gliomas visible on MRI who are planning to receive radiotherapy or
- Patients with brain metastases\>1cm who are planning to receive radiotherapy
- Karnofsky Performance Status \>60
- Age 18 years
- Patients must be willing to visit Toronto Western Hospital for at least one MRI scan prior radiotherapy
Exclusion
- Seizures not controlled with medications, or non compliance with prescribed anti-seizure medication
- Prior radiation therapy to the brain
- Pregnancy
- Unwilling or unable to co-operate with breathing maneuvers
- Respiratory or cardiac limitations to breathing at 20 L/min
- Medical contra-indications to limited hypercapnia or hypocapnia (known increased intracerebral pressure, metabolic acidosis or alkalosis)
- Contraindication to MRI (patients weighing\>136 kgs-weight limit for the scanner tables; allergy to MR contrast agent; patients with pacemakers, cerebral aneurysm clips, shrapnel injury or implantable electronic devices not compatible with MRI)
- Other medical conditions deemed by the PI or associates to make the patients ineligible for protocol procedures
Key Trial Info
Start Date :
February 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00297024
Start Date
February 1 2005
End Date
May 1 2013
Last Update
January 6 2014
Active Locations (1)
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1
University Health Network
Toronto, Ontario, Canada, M5G 2M9