Status:
COMPLETED
Macrophage Phagocytosis in COPD
Lead Sponsor:
Imperial College London
Conditions:
Chronic Obstructive Pulmonary Disease
Emphysema
Eligibility:
All Genders
21-75 years
Brief Summary
Patients with chronic obstructive pulmonary disease (COPD) that have frequent chest infections are the patients most likely to become worse over time. Why these people are more susceptible to chest in...
Detailed Description
Chronic obstructive pulmonary disease (COPD) comprises chronic bronchitis, small airways disease and emphysema. The major risk factor for the development of COPD is cigarette smoking therefore, the pr...
Eligibility Criteria
Inclusion
- Healthy non-smoking subjects:
- All normal volunteers will meet the following criteria:
- Age 21-75 years. No history of respiratory or allergic disease. Normal baseline spirometry as predicted for age, sex and height. Non-smokers. No history of upper respiratory tract infection in the preceding six weeks. Not taking regular medication
- COPD subjects:
- COPD is diagnosed according to American Thoracic Society, European Respiratory Society and British Thoracic Society guidelines by the doctors in Professor Barnes' COPD clinic.
- All COPD volunteers will meet the following criteria:
- Age between 35-75 years. A smoking history of at least 10 pack years. ( 1 pack year = 20 cigarettes per day for 1 year) FEV1:FVC ratio of \<0.7, post-bronchodilator FEV1 of \<85% predicted, reversibility with inhaled beta2-agonist of \<15% of predicted FEV1: all three criteria are required.
Exclusion
- Subjects will not included in this study if they meet any of the following exclusion criteria:
- Clinically significant findings in the medical history or on physical examination other than those of COPD in the COPD group.
- Pregnant women or mothers who are breastfeeding. Subjects who are unable to give informed consent.-
Key Trial Info
Start Date :
October 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT00298389
Start Date
October 1 2005
End Date
December 1 2010
Last Update
December 3 2019
Active Locations (1)
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1
Imperial College London
London, United Kingdom, SW3 6LY