Status:
WITHDRAWN
Macrophages in Smokers' Lung
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Chronic Obstructive Pulmonary Disease
Emphysema
Eligibility:
All Genders
21-70 years
Brief Summary
Cigarette smoking causes an increase in inflammation in the lungs. In about 20% of smokers this inflammation leads to damage in lungs including making holes in the lung tissue. This damage can not be ...
Detailed Description
Chronic obstructive pulmonary disease, or COPD for short, will be 3rd biggest killer in the world by 2020. The major cause of this disease is cigarette smoking, but only about 15-20% of smokers will d...
Eligibility Criteria
Inclusion
- All healthy smoking volunteers in trials will meet the following criteria:
- Age 21-70 years. Smoking history of at least 10 pack years. (1 pack year = 20 cigarettes per day for 1 year).
- No history of respiratory or allergic disease. Normal baseline spirometry as predicted for age, sex and height. No history of upper respiratory tract infection in the preceding six weeks. Not taking regular medication -
Exclusion
- Subjects will not included in this study if they meet any of the following exclusion criteria:
- Clinically significant findings in the medical history or on physical examination.
- Pregnant women or mothers who are breastfeeding. Subjects who are unable to give informed consent -
Key Trial Info
Start Date :
October 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00298402
Start Date
October 1 2005
End Date
October 1 2007
Last Update
May 28 2015
Active Locations (1)
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1
Imperial College London
London, United Kingdom, SW3 6LY